Data Resource Portal at a Glance

Why Create the Kids First Data Resource Portal?

There are currently limited resources for researchers studying the underlying genetics of pediatric diseases. Cancer and birth defects represent a landscape of highly complex and poorly understood diseases. While there is already a healthy web-based research ecosystem for adult cancer genomics data there is no comprehensive portal for pediatric cancers. Additionally, there are few web- or application-based tools to assist researchers investigating the causes and consequences of structural birth defects, and no online resources that combine the phenotypic and genotype information for these two classes of pediatric disease. This is despite abundant evidence that structural birth defects and pediatrics cancers share common causation and biological pathways including such relatively common syndromes as Down, Klinefelter, Wiskott-Aldrich, Noonan, and Perlman, are associated with elevated cancer risk. The Kids First Data Resource Portal brings together the childhood cancer and structural birth defect research communities, providing a unique combination of large-scale integrated data resources and scalable cloud-based computation for researchers to leverage the information gathered by one community to acquire insights in the other, and to recognize and promote collaborations among the two disciplines and across diverse expertise.

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